Corvinus
Corvinus

Patient and general population values for luminal and perianal fistulising Crohn’s disease health states

Rencz, Fanni and Stalmeier, Peep F. M. and Péntek, Márta and Brodszky, Valentin and Ruzsa, Gábor and Gönczi, Lóránt and Palatka, Károly and Herszényi, László and Schäfer, Eszter and Banai, János and Rutka, Mariann and Gulácsi, László and Lakatos, Péter L. (2019) Patient and general population values for luminal and perianal fistulising Crohn’s disease health states. The European Journal of Health Economics, 2019 (20). S91-S100. DOI https://doi.org/10.1007/s10198-019-01065-y

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Official URL: https://doi.org/10.1007/s10198-019-01065-y

A nyílt hozzáférést az EISZ és a kiadó között létrejött "Read and Publish" szerződés biztosította. Open access was provided "Read and Publish" contract between EIS and the publisher.

Abstract

Background In patients with Crohn’s disease (CD), luminal disease activity paralleled by perianal fstulas may seriously impair health-related quality of life (HRQoL). Health utility values are not available from patients with CD that refect the health loss associated with both luminal and perianal CD. Objective To generate utilities for luminal and concomitant perianal fstulising CD health states directly from patients and from members of the general public. Methods A cross-sectional survey was undertaken enrolling CD patients and a convenience sample of members of the general population. Respondents were asked to evaluate four common CD heath states [severe luminal disease (sCD), mild luminal disease (mCD), severe luminal disease with active perianal fstulas (sPFCD), and mild luminal disease with active perianal fstulas (mPFCD)] by 10-year time trade-of (TTO). In addition, patients assessed their current HRQoL by the TTO method. Results Responses of 206 patients (40.8% with perianal fstulas) and 221 members of the general population were analysed. Mean±SD utilities among patients for sPFCD, sCD, mPFCD and mCD states were 0.69±0.33, 0.73±0.31, 0.80±0.29 and 0.87±0.26. Corresponding values in the general public were: 0.59±0.31, 0.65±0.29, 0.80±0.26 and 0.88±0.25. Patients with active perianal fstulas, previous non-resection surgeries, and higher pain intensity scores valued their current health as worse (p<0.05). Conclusions TTO is a feasible method to assess HRQoL in patients with perianal fstulising disease, often not captured by health status questionnaires. Utilities from this study are intended to support the optimization of treatment-related decision making in patients with luminal disease paralleled by active perianal fstulas.

Item Type:Article
Uncontrolled Keywords:Crohn’s disease, perianal fistula, quality of life, time trade-of, utility, QALY, Hungary
JEL classification:I10 - Health: General
Subjects:Sociology
Social welfare, insurance, health care
DOI:https://doi.org/10.1007/s10198-019-01065-y
ID Code:5316
Deposited By: Veronika Vitéz
Deposited On:04 Apr 2020 15:12
Last Modified:04 Apr 2020 15:12

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